α-Oxo Aldehyde or Glyoxylyl Group Chemistry in Peptide Bioconjugation

El-Mahdi O. and Melnyk O. Bioconjugate Chem. 2013, 24, 735


Highly efficient solid phase synthesis of large polypeptides by iterative ligations of bis(2-sulfanylethyl)amido (SEA) peptide segments

Raibaut L., Adihou H., Desmet R., F. Delmas A., Aucagne V. and Melnyk O. Chem. Sci., 2013,4, 4061


Total synthesis of biotinylated N domain of human hepatocyte growth factor

Raibaut L., Vicogne J., Leclercq B., Drobecq H., Desmet R., Melnyk O. Bioorg. Med. Chem. 2013, 21, 3486




Sequential Native Peptide Ligation Strategies For Total Chemical Protein Synthesis

Raibaut L., Ollivier N., Melnyk O. Chem. Soc. Rev. 2012, 41, 7001.


Access to cyclic or branched peptides using bis(2-sulfanylethyl)amido side-chain derivatives of Asp and Glu

Boll E., Dheur J., Drobecq H., Melnyk O. Org. Lett. 2012, 14, 2222


A One-Pot Three-Segment Ligation Strategy for Protein Chemical Synthesis

Ollivier O., Vicogne J., Vallin A., Drobecq H., Desmet R., El Mahdi O., Leclercq B., Goormachtigh G., Fafeur V.,
Melnyk O. Angewandte Chem. Int. Ed. 2012, 51, 209




Synthesis of Peptide Alkylthioesters Using the Intramolecular N,S-Acyl Shift Properties of Bis(2-sulfanylethyl)amido Peptides

Dheur J., Ollivier N., Vallin A. and Melnyk O. J. Org. Chem. 2011, 76, 3194


Synthesis of Thiazolidine Thioester Peptides and Acceleration of Native Chemical Ligation

Dheur J., Ollivier N. and Melnyk O. Org. Lett. 2011, 13, 1560




Bis(2-sulfanylethyl)amino Native Peptide Ligation

Ollivier N., Dheur J., Mhidia R., Blanpain A. and Melnyk O. Org. Lett. 2010, 12, 5238