Catégories

 

PUBLICATIONS

 

2013


α-Oxo Aldehyde or Glyoxylyl Group Chemistry in Peptide Bioconjugation

El-Mahdi O. and Melnyk O. Bioconjugate Chem. 2013, 24, 735

 

Highly efficient solid phase synthesis of large polypeptides by iterative ligations of bis(2-sulfanylethyl)amido (SEA) peptide segments

Raibaut L., Adihou H., Desmet R., F. Delmas A., Aucagne V. and Melnyk O. Chem. Sci., 2013,4, 4061

 

Total synthesis of biotinylated N domain of human hepatocyte growth factor

Raibaut L., Vicogne J., Leclercq B., Drobecq H., Desmet R., Melnyk O. Bioorg. Med. Chem. 2013, 21, 3486

 

 

2012


Sequential Native Peptide Ligation Strategies For Total Chemical Protein Synthesis

Raibaut L., Ollivier N., Melnyk O. Chem. Soc. Rev. 2012, 41, 7001.

 

Access to cyclic or branched peptides using bis(2-sulfanylethyl)amido side-chain derivatives of Asp and Glu

Boll E., Dheur J., Drobecq H., Melnyk O. Org. Lett. 2012, 14, 2222

 

A One-Pot Three-Segment Ligation Strategy for Protein Chemical Synthesis

Ollivier O., Vicogne J., Vallin A., Drobecq H., Desmet R., El Mahdi O., Leclercq B., Goormachtigh G., Fafeur V.,
Melnyk O. Angewandte Chem. Int. Ed. 2012, 51, 209

 

 

2011


Synthesis of Peptide Alkylthioesters Using the Intramolecular N,S-Acyl Shift Properties of Bis(2-sulfanylethyl)amido Peptides

Dheur J., Ollivier N., Vallin A. and Melnyk O. J. Org. Chem. 2011, 76, 3194

 

Synthesis of Thiazolidine Thioester Peptides and Acceleration of Native Chemical Ligation

Dheur J., Ollivier N. and Melnyk O. Org. Lett. 2011, 13, 1560

 

 

2010


Bis(2-sulfanylethyl)amino Native Peptide Ligation

Ollivier N., Dheur J., Mhidia R., Blanpain A. and Melnyk O. Org. Lett. 2010, 12, 5238